|
KMID : 0366220050400020116
|
|
Korean Journal of Hematology
2005 Volume.40 No. 2 p.116 ~ p.119
|
|
|
A Case of Autoimmune Hemolytic Anemia after Fludarabine Treatment in Waldenstrom Macroglobulinemia
|
|
Moon Seung-Hwan
Chung Seuk-Hee
Jung Dong-Sik
Lee Chang-Jae
Seo Bong-Gun
Kim Sung-Hyun
Kwon Hyuk-Chan
Kim Jae-Seok
Kim Hyo-Jin
|
|
|
Abstract
|
|
|
|
Waldenstrom macroglobulinemia, that is characterized by elevation of serum monoclonal IgM paraprotein, has been responsed for treatment of purine analogues recently. Fludarabine, one of purine analogues, has been associated with autoimmune hemolytic anemia in patient with chronic lymphocytic leukemia. However, autoimmune hemolytic anemia after fludarabine treatment for Waldenstrom macroglobulinemia has not been reported. We experienced a case of autoimmune hemolytic anemia after fludarabine treatment for Waldenstrom macroglobulinemia. In this case, hemolytic anemia with positive direct Coombs’ test occurred at 20 months after the first administration of fludarabine, relapsed at 5 days after readministration. This anemia was responsed to steroid therapy. Autoimmune hemolytic anemia associated with fludarabine therapy can be severe and fatal, especially if a patient is retreated with this drug after a previous episode of hemolytic anemia.
|
|
|
KEYWORD
|
|
|
Autoimmune hemolytic anemia, Waldenstrom macroglobulinemia, Fludarabine
|
|
|
FullTexts / Linksout information
|
|
  
|
|
|
Listed journal information
|
|
  
|